Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical purpose and pharmacology out of curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the significant element of the new red-colored dye from turmeric, a keen Indian liven which is taken from the fresh rhizome of exotic bush Curcuma longa, and therefore is one of the Zingiberaceae family unit members. In this part, i discuss the pharmacological items out-of curcumin and you can explore the unit bases of these products. We upcoming remark the shown and possible logical uses regarding curcumin. Curcumin is famous typically because the a curative broker, but its mechanism out-of step try detail by detail. New pharmacological aftereffects of curcumin appear to be caused by good synergism out of companies out-of poor biochemical connections which have multiple helt gratis rumänska dejtingsajter physiological purpose in interrelated signaling pathways. These types of goals include enzymes such as cyclooxygenase, lipoxygenase and necessary protein kinases, and you can transcription situations such NF-?B, STAT and you can Nrf2. Modulation of those particles impacts downstream affectors which make the brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial factors from curcumin. Such consequences have been checked out in the clinical products from curcumin having pain and you can inflammatory problems, cancers, Alzheimer problem, cardiovascular problems, and you may all forms of diabetes. This new trials have tried varying amounts out-of curcuminwith some other frequencies and duration, on general conclusion one higher dosages from curcumin during the number of grams are required to see healing effects. Read more
Curcumin: Synthesis, Growing Part inside the Problems Government and you can Wellness Ramifications
Book Section Types of bush-derived pharmaceuticals with become the appeal of continuous and you will exponential lookup and you may advancement focus possess, up to now, become some scarce. Immediately after many years, the past 2 decades was basically characterized by a great 100-bend upsurge in the number of medical stuff published annually one to is actually away from advantages on the usage of curcumin inside the biomedicine. Read more
Construction, synthesis and you will physiological things out of curcumin prodrugs
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many prospective pharmacological effects that will provides healing programs in several disease claims, since talked about in detail in the previous section. Yet not, the possibility scientific efficacy away from curcumin is limited of the their physicochemical properties of poor h2o solubility and you can instability, and this trigger reduced bioavailability. Prodrugs from curcumin provide an effective way to improve of the biopharmaceutical and you can pharmacokinetic features, and will ensure it is exploitation of pharmacological aftereffects of curcumin. Within this chapter, i very first comment the physicochemical and you may pharmacokinetics from curcumin. We then identify the design of curcumin prodrugs with increased drinking water solubility and you may enhanced agents stability and this can be translated to 100 % free curcumin upon bioactivation when you look at the vivo. We high light recent triumph here, with a concentrate on the construction, synthesis and you can analysis out-of prodrugs according to promoieties and additionally amino acids, essential fatty acids, nucleic acids, dicarboxylic acids, and you can polymeric materials like hyaluronic acidic and you will polyethylene glycol. So it chapter has the cause for optimisation of your physicochemical and you may biopharmaceutical features as well as the physical circumstances away from curcumin prodrugs, into the objective having fun with of them curcumin derivatives inside health-related programs. Find out more